Target：RNF6

Gene Name：RNF6 SPG2

Protein Name：E3 ubiquitin-protein ligase RNF6 (EC 6.3.2.-)

Human Gene Id：6049

Human Swiss Prot No：Q9Y252

Mouse Swiss Prot No：Q9DBU5

Immunogen：Synthesized peptide derived from human protein . at AA range: 470-550

Specificity：RNF6 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：75kD

Background： The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008],

Function：similarity:Contains 1 RING-type zinc finger.,tissue specificity:Weakly expressed in peripheral blood, spleen, prostate, testis and ovary.,

Subcellular Location：Nucleus . Cytoplasm . Cell projection, axon . Nucleus, PML body . Localizes to the PML nuclear bodies in Sertoli cells. .

Expression：Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.