Main Information

Target

Keratin 77

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

IHC, IF, WB

MW

61kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; WB 1:500-2000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human Keratin 77

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

61kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human Keratin 77

Specificity:

This antibody detects endogenous levels of human Keratin 77

Gene Name:

KRT77 KRT1B

Protein Name:

Keratin 77

Other Name:

Keratin, type II cytoskeletal 1b ;
Cytokeratin-1B ;
CK-1B ;
Keratin-77 ;
K77 ;
Type-II keratin Kb39 ;

Database Link:

Organism	Gene ID	SwissProt
Human	374454;	Q7Z794;

Background:

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009],

Function:

miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Undergoes deimination of some arginine residues (citrullination).,similarity:Belongs to the intermediate filament family.,tissue specificity:Expressed exclusively in skin.,

Cellular Localization:

cytoskeleton,intermediate filament,keratin filament,extracellular exosome,

Tissue Expression:

Expressed exclusively in skin.