Main Information

Target

MAGE1

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB, ELISA

MW

105kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:500-2000; ELISA 1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Specificity

MAGE1 Polyclonal Antibody detects endogenous levels of protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

105kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human protein . at AA range: 760-840

Specificity:

MAGE1 Polyclonal Antibody detects endogenous levels of protein.

Gene Name:

MAGEE1 HCA1 KIAA1587

Protein Name:

Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (Hepatocellular carcinoma-associated protein 1) (MAGE-E1 antigen)

Database Link:

Organism	Gene ID	SwissProt
Human	57692;	Q9HCI5;
Mouse		Q6PCZ4;
Rat		A1A5P9;

Background:

This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to mental retardation. [provided by RefSeq, Mar 2010],

Function:

similarity:Contains 2 MAGE domains.,

Cellular Localization:

Cytoplasm, perinuclear region . Nucleus . Cell membrane . In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity). .

Tissue Expression:

Brain,PNS,Testis,