Target：Casein Kinase IIα
Fields：Ribosome biogenesis in eukaryotes;NF-kappa B signaling pathway;Mitophagy - animal;Wnt signaling pathway;Adherens junction;Alzheimer disease;Prion disease;Pathways of neurodegeneration - multiple diseases;Measles;PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Name：CSNK2A1
Protein Name：Casein kinase II subunit alpha
Human Gene Id：1457
Human Swiss Prot No：P68400
Mouse Gene Id：12995
Mouse Swiss Prot No：Q60737
Rat Gene Id：116549
Rat Swiss Prot No：P19139
Immunogen：The antiserum was produced against synthesized peptide derived from human Casein Kinase II alpha around the phosphorylation site of Tyr255. AA range:221-270
Specificity：Phospho-Casein Kinase IIα (Y255) Polyclonal Antibody detects endogenous levels of Casein Kinase IIα protein only when phosphorylated at Y255.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CSNK2A1;CK2A1;Casein kinase II subunit alpha;CK II alpha
Observed Band(KD)：45kD
Background： Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014],
Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with RNPS1.,
Subcellular Location：Nucleus .
Expression：Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level).
