Target：CaMK2
Fields：ErbB signaling pathway;Calcium signaling pathway;cAMP signaling pathway;HIF-1 signaling pathway;Oocyte meiosis;Necroptosis;Adrenergic signaling in cardiomyocytes;Wnt signaling pathway;Axon guidance;Circadian entrainment;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Olfactory transduction;Inflammatory mediator regulation of TRP channels;Insulin secretion;GnRH signaling pathway;Melanogenesis;Oxytocin signaling pathway;Glucagon signaling pathway;Aldosterone synthesis and secretion;Cushing syndrome;Gastric acid secretion;Parkinson disease;Pathways of neurodegeneration - multiple diseases;Amphetamine addiction;Tuberculosis;Pathways in cancer;Proteoglycans in cancer;Glioma;Diabetic cardiomyopathy;Lipid and atherosclerosis
Gene Name：CAMK2A/CAMK2D
Protein Name：Calcium/calmodulin-dependent protein kinase type II subunit alpha/delta
Human Gene Id：815/817
Human Swiss Prot No：Q9UQM7/Q13557
Mouse Gene Id：12322/108058
Rat Gene Id：25400/24246
Rat Swiss Prot No：P11275/P15791
Immunogen：The antiserum was produced against synthesized peptide derived from human CaMK2 around the phosphorylation site of Thr286. AA range:256-305
Specificity：Phospho-CaMKIIα/δ (T286) Polyclonal Antibody detects endogenous levels of CaMKIIα/δ protein only when phosphorylated at T286.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CAMK2A;CAMKA;KIAA0968;Calcium/calmodulin-dependent protein kinase type II subunit alpha;CaM kinase II subunit alpha;CaMK-II subunit alpha;CAMK2D;CAMKD;Calcium/calmodulin-dependent protein kinase type II subunit delta;CaM kinase II
Observed Band(KD)：54kD
Background： The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008],
Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Postsynaptic lipid rafts.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric
Subcellular Location：Cell junction, synapse . Cell junction, synapse, postsynaptic density . Cell projection, dendritic spine . Cell projection, dendrite . Postsynaptic lipid rafts. .
Expression： Brain,
