Target：CaMKIIβ/γ/δ
Fields：ErbB signaling pathway;Calcium signaling pathway;cAMP signaling pathway;HIF-1 signaling pathway;Oocyte meiosis;Necroptosis;Adrenergic signaling in cardiomyocytes;Wnt signaling pathway;Axon guidance;Circadian entrainment;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Olfactory transduction;Inflammatory mediator regulation of TRP channels;Insulin secretion;GnRH signaling pathway;Melanogenesis;Oxytocin signaling pathway;Glucagon signaling pathway;Aldosterone synthesis and secretion;Cushing syndrome;Gastric acid secretion;Parkinson disease;Pathways of neurodegeneration - multiple diseases;Amphetamine addiction;Tuberculosis;Pathways in cancer;Proteoglycans in cancer;Glioma;Diabetic cardiomyopathy;Lipid and atherosclerosis
Gene Name：CAMK2B
Protein Name：Calcium/calmodulin-dependent protein kinase type II subunit beta
Human Gene Id：816/818/817
Human Swiss Prot No：Q13554/Q13555/Q13557
Mouse Gene Id：12323/12325/108058
Rat Gene Id：24245/171140/24246
Rat Swiss Prot No：P08413/P11730/P15791
Immunogen：The antiserum was produced against synthesized peptide derived from human CaMK2-beta/gamma/delta around the phosphorylation site of Thr287. AA range:253-302
Specificity：Phospho-CaMKIIβ/γ/δ (T287) Polyclonal Antibody detects endogenous levels of CaMKIIβ/γ/δ protein only when phosphorylated at T287.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CAMK2B;CAM2;CAMK2;CAMKB;Calcium/calmodulin-dependent protein kinase type II subunit beta;CaM kinase II subunit beta;CaMK-II subunit beta;CAMK2G;CAMK;CAMK-II;CAMKG;Calcium/calmodulin-dependent protein kinase type II subunit gamma;
Observed Band(KD)：50kD,65kD
Background： The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
Function：alternative products:The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different
Subcellular Location：Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.
Expression：Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
