Target：ZIS

Gene Name：ZRANB2

Protein Name：Zinc finger Ran-binding domain-containing protein 2

Human Gene Id：9406

Human Swiss Prot No：O95218

Mouse Gene Id：53861

Mouse Swiss Prot No：Q9R020

Rat Gene Id：58821

Rat Swiss Prot No：O35986

Immunogen：The antiserum was produced against synthesized peptide derived from human ZNF265. AA range:106-155

Specificity：ZIS Polyclonal Antibody detects endogenous levels of ZIS protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ZRANB2;ZIS;ZNF265;Zinc finger Ran-binding domain-containing protein 2;Zinc finger protein 265;Zinc finger; splicing

Observed Band(KD)：34kD

Background：domain:The RanBP2-type zinc fingers mediate binding to RNA.,function:Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.,PTM:Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.,sequence caution:Intron retention.,similarity:Belongs to the ZRANB2 family.,similarity:Contains 2 RanBP2-type zinc fingers.,subunit:Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of XE7 as well as with U2AF1 and CLK1.,

Function：domain:The RanBP2-type zinc fingers mediate binding to RNA.,function:Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.,PTM:Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.,sequence caution:Intron retention.,similarity:Belongs to the ZRANB2 family.,similarity:Contains 2 RanBP2-type zinc fingers.,subunit:Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of XE7 as well as with U2AF1 and CLK1.,

Subcellular Location：Nucleus .

Expression： Brain,Epithelium,Fetal brain,Fetal kidney,Liver,Skin,Testis,Uterus,