Target：IRS-1
Fields：cGMP-PKG signaling pathway;FoxO signaling pathway;Autophagy - animal;mTOR signaling pathway;PI3K-Akt signaling pathway;AMPK signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;Neurotrophin signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Regulation of lipolysis in adipocytes;Type II diabetes mellitus;Insulin resistance;Non-alcoholic fatty liver disease;Growth hormone synthesis, secretion and action;Aldosterone-regulated sodium reabsorption;Alzheimer disease;MicroRNAs in cancer;Diabetic cardiomyopathy
Gene Name：IRS1
Protein Name：Insulin receptor substrate 1
Human Gene Id：3667
Human Swiss Prot No：P35568
Mouse Swiss Prot No：P35569
Rat Swiss Prot No：P35570
Immunogen：The antiserum was produced against synthesized peptide derived from human IRS-1 around the phosphorylation site of Ser794. AA range:760-809
Specificity：Phospho-IRS-1 (S794) Polyclonal Antibody detects endogenous levels of IRS-1 protein only when phosphorylated at S794.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：IRS1;Insulin receptor substrate 1;IRS-1
Observed Band(KD)：170kD
Background： This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009],
Function：disease:Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].,function:May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.,polymorphism:The Arg-971 polymorphism impairs the ability of insulin to stimulate glucose transport, glucose transporter translocation, and glycogen synthesis by affecting the PI3K/AKT1/GSK3 signaling pathway. The polymorphism at Arg-971 may contribute to the in vivo insulin resistance observed in carriers of this variant. Arg-971 could contribute to the risk for atherosclerotic cardiovascular diseases associated with non-insulin-dependen
Subcellular Location：nucleus,cytoplasm,cytosol,plasma membrane,insulin receptor complex,caveola,intracellular membrane-bounded organelle,
Expression： Epithelium,Eye,Skeletal muscle,
