Target：IRS-1

Fields：cGMP-PKG signaling pathway;FoxO signaling pathway;Autophagy - animal;mTOR signaling pathway;PI3K-Akt signaling pathway;AMPK signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;Neurotrophin signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Regulation of lipolysis in adipocytes;Type II diabetes mellitus;Insulin resistance;Non-alcoholic fatty liver disease;Growth hormone synthesis, secretion and action;Aldosterone-regulated sodium reabsorption;Alzheimer disease;MicroRNAs in cancer;Diabetic cardiomyopathy

Gene Name：IRS1

Protein Name：Insulin receptor substrate 1

Human Gene Id：3667

Human Swiss Prot No：P35568

Mouse Gene Id：16367

Mouse Swiss Prot No：P35569

Rat Gene Id：25467

Rat Swiss Prot No：P35570

Immunogen：The antiserum was produced against synthesized peptide derived from human IRS-1 around the phosphorylation site of Ser639. AA range:605-654

Specificity：Phospho-IRS-1 (S639) Polyclonal Antibody detects endogenous levels of IRS-1 protein only when phosphorylated at S639.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IRS1;Insulin receptor substrate 1;IRS-1

Observed Band(KD)：170kD

Background： This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009],

Function：disease:Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].,function:May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.,polymorphism:The Arg-971 polymorphism impairs the ability of insulin to stimulate glucose transport, glucose transporter translocation, and glycogen synthesis by affecting the PI3K/AKT1/GSK3 signaling pathway. The polymorphism at Arg-971 may contribute to the in vivo insulin resistance observed in carriers of this variant. Arg-971 could contribute to the risk for atherosclerotic cardiovascular diseases associated with non-insulin-dependen

Subcellular Location：nucleus,cytoplasm,cytosol,plasma membrane,insulin receptor complex,caveola,intracellular membrane-bounded organelle,

Expression： Epithelium,Eye,Skeletal muscle,