Target：SgK269

Gene Name：PEAK1

Protein Name：Pseudopodium-enriched atypical kinase 1

Human Gene Id：79834

Human Swiss Prot No：Q9H792

Mouse Swiss Prot No：Q69Z38

Immunogen：The antiserum was produced against synthesized peptide derived from human SGK269. AA range:111-160

Specificity：SgK269 Polyclonal Antibody detects endogenous levels of SgK269 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PEAK1;KIAA2002;Pseudopodium-enriched atypical kinase 1;Sugen kinase 269;Tyrosine-protein kinase SgK269

Observed Band(KD)：195kD

Background： This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014],

Function：catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,

Subcellular Location：Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Colocalizes with F-actin in serum-rich medium (PubMed:20534451). Actin colocalization is reduced during serum starvation (PubMed:20534451). .

Expression： Brain,Epithelium,Lung,Mesangial cell,Smooth muscle,Spleen,