Target：SGK2

Fields：FoxO signaling pathway;PI3K-Akt signaling pathway

Gene Name：SGK2

Protein Name：Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2)

Human Gene Id：10110

Human Swiss Prot No：Q9HBY8

Mouse Swiss Prot No：Q9QZS5

Rat Swiss Prot No：Q8R4U9

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：SGK2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：46kD

Background： This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:Not regulated by serum or glucocorticoids.,enzyme regulation:Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser-416), need to be phosphorylated for its full activation.,function:Involved in the activation of potassium channels.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highly expressed in liver, kidney and pancreas, and at lower levels in brain.,

Subcellular Location：Cytoplasm . Nucleus .

Expression：Highly expressed in liver, kidney and pancreas, and at lower levels in brain.