Target：TKN1

Fields：Neuroactive ligand-receptor interaction

Gene Name：TAC1 NKA NKNA TAC2

Protein Name：Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]

Human Gene Id：6863

Human Swiss Prot No：P20366

Mouse Swiss Prot No：P41539

Rat Swiss Prot No：P06767

Immunogen：Synthesized peptide derived from human protein . at AA range: 20-100

Specificity：TKN1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：14kD

Background： This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014],

Function：function:Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.,online information:Neurokinin-1 entry,similarity:Belongs to the tachykinin family.,

Subcellular Location：Secreted.

Expression： Adrenal medulla,Blood,Brain,Small intestine,Testis,