Target：SETMAR

Fields：Lysine degradation;Metabolic pathways

Gene Name：SETMAR

Protein Name：Histone-lysine N-methyltransferase SETMAR

Human Gene Id：6419

Human Swiss Prot No：Q53H47

Mouse Swiss Prot No：Q80UJ9

Immunogen：The antiserum was produced against synthesized peptide derived from human SETMAR. AA range:350-400

Specificity：SETMAR Polyclonal Antibody detects endogenous levels of SETMAR protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SETMAR;Histone-lysine N-methyltransferase SETMAR;SET domain and mariner transposase fusion gene-containing protein;HsMar1;Metnase

Molecular Weight(Da)：77kD

Background： This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],

Function：catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,domain:The mariner transposase Hsmar1 region mediates DNA-binding. It has no transposase activity because the active site contains an Asn in position 610 instead of a Asp residue.,function:Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Binds DNA. May play a role in non-homologous end-joining repair.,miscellaneous:The mariner transposase region in only present in primates and appeared 40-58 million years ago, after the insertion of a transposon downstream of a preexisting SET gene, followed by the de novo exonization of previously non-coding sequence and the creation of a new intron.,similarity:Contains 1 post-SET domain.,similar

Subcellular Location：Nucleus . Chromosome . Recruited on damaged DNA at sites of double-strand breaks. .

Expression：Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.