Target：SF-1

Fields：Cortisol synthesis and secretion;Cushing syndrome

Gene Name：NR5A1

Protein Name：Steroidogenic factor 1

Human Gene Id：2516

Human Swiss Prot No：Q13285

Mouse Gene Id：26423

Mouse Swiss Prot No：P33242

Rat Gene Id：83826

Rat Swiss Prot No：P50569

Immunogen：The antiserum was produced against synthesized peptide derived from human NR5A1. AA range:169-218

Specificity：SF-1 Polyclonal Antibody detects endogenous levels of SF-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NR5A1;AD4BP;FTZF1;SF1;Steroidogenic factor 1;SF-1;STF-1;Adrenal 4-binding protein;Fushi tarazu factor homolog 1;Nuclear receptor subfamily 5 group A member 1;Steroid hormone receptor Ad4BP

Observed Band(KD)：50kD

Background： The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008],

Function：disease:Defects in NR5A1 are a cause of adrenocortical insufficiency without ovarian defect [MIM:184757]. The disease is characterized by severe 'slackness,' muscular hypotonia. There is decreased sodium, increased potassium and elevated ACTH.,disease:Defects in NR5A1 are a cause of XY sex reversal with or without adrenal failure [MIM:184757]. This disease is characterized by normal female external genitalia and retention of the uterus.,function:Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NO

Subcellular Location：Nucleus .

Expression：High expressed in the adrenal cortex, the ovary, the testis, and the spleen (PubMed:9177385).