Target：SETB2
Fields：Lysine degradation;Metabolic pathways
Gene Name：SETDB2 C13orf4 CLLD8 KMT1F
Protein Name：Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.43) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2)
Human Gene Id：83852
Human Swiss Prot No：Q96T68
Mouse Swiss Prot No：Q8C267
Immunogen：Synthesized peptide derived from part region of human protein
Specificity：SETB2 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：79kD
Background：SET domain bifurcated 2(SETDB2) Homo sapiens This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
Function：catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,function:Probable histone methyltransferase.,similarity:Belongs to the histone-lysine methyltransferase family.,similarity:Contains 1 MBD (methyl-CpG-binding) domain.,similarity:Contains 1 pre-SET domain.,similarity:Contains 1 SET domain.,tissue specificity:Ubiquitous. Highest expression in heart, testis and ovary.,
Subcellular Location：Nucleus . Chromosome .
Expression：Ubiquitous. Highest expression in heart, testis and ovary.
