Target：GRK 7

Fields：Chemokine signaling pathway;Endocytosis;Phototransduction

Gene Name：GRK7

Protein Name：G protein-coupled receptor kinase 7

Human Gene Id：131890

Human Swiss Prot No：Q8WTQ7

Immunogen：The antiserum was produced against synthesized peptide derived from human GRK7. AA range:371-420

Specificity：GRK 7 Polyclonal Antibody detects endogenous levels of GRK 7 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GRK7;GPRK7;G protein-coupled receptor kinase 7;G protein-coupled receptor kinase GRK7

Observed Band(KD)：62kD

Background： This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Phosphorylates cone opsins thereby initiating their deactivation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Retina. Cones and rod.,

Subcellular Location：Membrane ; Lipid-anchor .

Expression：Retinal cones, outer and inner segments.