Target：GRK 6
Fields：Chemokine signaling pathway;Endocytosis;Morphine addiction
Gene Name：GRK6
Protein Name：G protein-coupled receptor kinase 6
Human Gene Id：2870
Human Swiss Prot No：P43250
Mouse Gene Id：26385
Mouse Swiss Prot No：O70293
Rat Swiss Prot No：P97711
Immunogen：The antiserum was produced against synthesized peptide derived from human GRK6. AA range:10-59
Specificity：GRK 6 Polyclonal Antibody detects endogenous levels of GRK 6 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：GRK6;GPRK6;G protein-coupled receptor kinase 6;G protein-coupled receptor kinase GRK6
Observed Band(KD)：65kD
Background： This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Function：catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Specifically phosphorylates the activated forms of G protein-coupled receptors.,PTM:It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Widely expressed.,
Subcellular Location：Membrane; Lipid-anchor.
Expression：Widely expressed.
