Target:Ran BP-17
Fields:Nucleocytoplasmic transport
Gene Name:RANBP17
Protein Name:Ran-binding protein 17
Human Gene Id:64901
Human Swiss Prot No:Q9H2T7
Mouse Gene Id:66011
Mouse Swiss Prot No:Q99NF8
Immunogen:The antiserum was produced against synthesized peptide derived from human RANBP17. AA range:145-194
Specificity:Ran BP-17 Polyclonal Antibody detects endogenous levels of Ran BP-17 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000;IHC 1:50-300
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:RANBP17;Ran-binding protein 17
Observed Band(KD):125kD
Background:RAN binding protein 17(RANBP17) Homo sapiens The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002],
Function:function:May function as a nuclear transport receptor.,similarity:Belongs to the exportin family.,subunit:Binds to nucleoporins and the GTP-bound form of Ran.,tissue specificity:Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.,
Subcellular Location:Cytoplasm . Nucleus . Nucleus, nuclear pore complex .
Expression:Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.