Target：RAMP3

Fields：Vascular smooth muscle contraction

Gene Name：RAMP3

Protein Name：Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)

Human Gene Id：10268

Human Swiss Prot No：O60896

Mouse Swiss Prot No：Q9WUP1

Rat Swiss Prot No：Q9JJ73

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：RAMP3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：16kD

Background： The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008],

Function：function:Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.,similarity:Belongs to the RAMP family.,subunit:Heterodimer of CALCRL and RAMP3.,tissue specificity:Strongly expressed in lung, breast, immune system and fetal tissues.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Membrane ; Single-pass type I membrane protein . Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Expression：Strongly expressed in lung, breast, immune system and fetal tissues.