Target：RANTES

Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;Chemokine signaling pathway;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;Cytosolic DNA-sensing pathway;TNF signaling pathway;Prion disease;Epithelial cell signaling in Helicobacter pylori infection;Shigellosis;Chagas disease;Human cytomegalovirus infection;Influenza A;Herpes simplex virus 1 infection;Rheumatoid arthritis;Lipid and atherosclerosis

Gene Name：CCL5

Protein Name：C-C motif chemokine 5

Human Gene Id：6352

Human Swiss Prot No：P13501

Mouse Gene Id：20304

Mouse Swiss Prot No：P30882

Rat Swiss Prot No：P50231

Immunogen：The antiserum was produced against synthesized peptide derived from human RANTES. AA range:35-84

Specificity：RANTES Polyclonal Antibody detects endogenous levels of RANTES protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CCL5;D17S136E;SCYA5;C-C motif chemokine 5;EoCP;Eosinophil chemotactic cytokine;SIS-delta;Small-inducible cytokine A5;T cell-specific protein P228;TCP228;T-cell-specific protein RANTES

Molecular Weight(Da)：10kD

Background： This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode

Function：function:Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.,induction:By mitogens.,mass spectrometry: PubMed:1380064,mass spectrometry: PubMed:15923218,mass spectrometry:O-glycosylated PubMed:1380064,online

Subcellular Location：Secreted.

Expression：Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.