Target：Recoverin

Fields：Phototransduction

Gene Name：RCVRN

Protein Name：Recoverin

Human Gene Id：5957

Human Swiss Prot No：P35243

Mouse Gene Id：19674

Mouse Swiss Prot No：P34057

Immunogen：The antiserum was produced against synthesized peptide derived from human Recoverin. AA range:107-156

Specificity：Recoverin Polyclonal Antibody detects endogenous levels of Recoverin protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RCVRN;RCV1;Recoverin;Cancer-associated retinopathy protein;Protein CAR

Observed Band(KD)：23kD

Background： This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008],

Function：disease:Identified as the antigen in cancer-associated retinopathy, an autoimmune disease of the retina caused by a tumor in another tissue.,function:Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.,miscellaneous:Binds two calcium ions; one with high affinity, the other with low affinity.,similarity:Belongs to the recoverin family.,similarity:Contains 4 EF-hand domains.,tissue specificity:Retina and pineal gland.,

Subcellular Location：Photoreceptor inner segment . Cell projection, cilium, photoreceptor outer segment . Photoreceptor outer segment membrane ; Lipid-anchor ; Cytoplasmic side . Perikaryon . Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity). Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity). .

Expression：Retina and pineal gland.