Target：HSP 90

Fields：Protein processing in endoplasmic reticulum;PI3K-Akt signaling pathway;Necroptosis;Antigen processing and presentation;NOD-like receptor signaling pathway;IL-17 signaling pathway;Th17 cell differentiation;Progesterone-mediated oocyte maturation;Estrogen signaling pathway;Salmonella infection;Pathways in cancer;Chemical carcinogenesis - receptor activation;Prostate cancer;Lipid and atherosclerosis;Fluid shear stress and atherosclerosis

Gene Name：HSP90AA1

Protein Name：Heat shock protein HSP 90-alpha

Human Gene Id：3320

Human Swiss Prot No：P07900

Mouse Gene Id：15519

Mouse Swiss Prot No：P07901

Rat Gene Id：299331

Rat Swiss Prot No：P82995

Immunogen：The antiserum was produced against synthesized peptide derived from human HSP90A. AA range:683-732

Specificity：HSP90A Polyclonal Antibody detects endogenous levels of HSP90A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HSP90AA1;HSP90A;HSPC1;HSPCA;Heat shock protein HSP 90-alpha;Heat shock 86 kDa;HSP 86;HSP86;Renal carcinoma antigen NY-REN-38

Observed Band(KD)：85kD

Background： The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],

Function：caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,function:Molecular chaperone.,function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.,

Subcellular Location：Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Expression： Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius