Target：OSR1
Gene Name：OXSR1
Protein Name：Serine/threonine-protein kinase OSR1
Human Gene Id：9943
Human Swiss Prot No：O95747
Mouse Gene Id：108737
Mouse Swiss Prot No：Q6P9R2
Immunogen：The antiserum was produced against synthesized peptide derived from human OSR1 around the phosphorylation site of Thr185. AA range:151-200
Specificity：Phospho-OSR1 (T185) Polyclonal Antibody detects endogenous levels of OSR1 protein only when phosphorylated at T185.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：OXSR1;KIAA1101;OSR1;Serine/threonine-protein kinase OSR1;Oxidative stress-responsive 1 protein
Observed Band(KD)：65kD
Background： The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008],
Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:By autophosphorylation on threonine.,function:Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT.,tissue specificity:Ubiquitously expressed in all tissue examined.,
Subcellular Location：Cytoplasm .
Expression：Ubiquitously expressed in all tissue examined.
