Target:AAA1
Gene Name:SLC7A10 ASC1
Protein Name:Asc-type amino acid transporter 1 (Asc-1) (Solute carrier family 7 member 10)
Human Gene Id:56301
Human Swiss Prot No:Q9NS82
Mouse Swiss Prot No:P63115
Rat Swiss Prot No:P63116
Immunogen:Synthesized peptide derived from human protein . at AA range: 200-280
Specificity:AAA1 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):57kD
Background: SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008],
Function:disease:Defects in SLC7A10 may be involved in cystinuria (CSNU) which arises from impaired transport of cystine and dibasic amino acids through the epithelial cells of the renal tubule and gastrointestinal tract. Three types of cystinuria have been described.,function:Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.,similarity:Belongs to the amino acid-polyamine-organocation (APC) superfamily.,subunit:Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.,tissue specificity:Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.,
Subcellular Location:Membrane ; Multi-pass membrane protein .
Expression:Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.