Target：A4GAT

Fields：Glycosphingolipid biosynthesis - lacto and neolacto series;Glycosphingolipid biosynthesis - globo and isoglobo series;Metabolic pathways

Gene Name：A4GALT A14GALT A4GALT1

Protein Name：Lactosylceramide 4-alpha-galactosyltransferase (EC 2.4.1.228) (Alpha-1,4-N-acetylglucosaminyltransferase) (Alpha-1,4-galactosyltransferase) (Alpha4Gal-T1) (CD77 synthase) (Globotriaosylceramide syntha

Human Gene Id：53947

Human Swiss Prot No：Q9NPC4

Mouse Swiss Prot No：Q67BJ4

Rat Swiss Prot No：Q9JI93

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：A4GAT Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：38kD

Background：alpha 1,4-galactosyltransferase(A4GALT) Homo sapiens The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015],

Function：catalytic activity:UDP-galactose + beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide.,domain:The conserved DXD motif is involved in enzyme activity.,function:Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.,online information:GlycoGene database,online information:Lactosylceramide 4-alpha-galactosyltransferase,pathway:Protein modification; protein glycosylation.,polymorphism:Different combinations or absence of the P blood group system antigens define 5 different phenotypes: P1, P2, P1(k), P2(k), and p. Genetic variation in A4GALT determines the p phenotype, which is rare and does not express any antigens. It is also known as null

Subcellular Location：Golgi apparatus membrane ; Single-pass type II membrane protein .

Expression：Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.