Main Information

Target

MAP-2

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

IHC, IF, WB

MW

280kD (Observed)

Conjugate/Modification

Phospho

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; WB 1:500-2000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous phospho levels of MAP2 (Phospho-Thr1616) at Human:T1616, Mouse:T1620, Rat:T1622

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

280kD

Modification

Phospho

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human MAP2 (Phospho-Thr1616)

Specificity:

This antibody detects endogenous phospho levels of MAP2 (Phospho-Thr1616) at Human:T1616, Mouse:T1620, Rat:T1622

Gene Name:

MAP2

Protein Name:

MAP2 (Phospho-Thr1616)

Other Name:

Microtubule-associated protein 2 ;
MAP-2 ;

Database Link:

Organism	Gene ID	SwissProt
Human	4133;	P11137;

Background:

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010],

Function:

Alternative products:Additional isoforms seem to exist,Function:The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.,PTM:MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,

Cellular Localization:

Cytoplasm, cytoskeleton . Cell projection, dendrite .

Tissue Expression:

Brain,Brain cortex,Epithelium,Pancreas,Testis,