Main Information

Target

Thrombospondin 1

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB, IHC

MW

130kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:500-2000; IHC 1:50-300

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human Thrombospondin 1

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

130kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human Thrombospondin 1

Specificity:

This antibody detects endogenous levels of human Thrombospondin 1

Gene Name:

THBS1 TSP TSP1

Protein Name:

Thrombospondin 1

Other Name:

Thrombospondin-1

Database Link:

Organism	Gene ID	SwissProt
Human	7057;	P07996;

Background:

thrombospondin 1(THBS1) Homo sapiens The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008],

Function:

Function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3.,similarity:Belongs to the thrombospondin family.,similarity:Contains 1 TSP C-terminal (TSPC) domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 1 VWFC domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 3 TSP type-1 domains.,similarity:Contains 8 TSP type-3 repeats.,subunit:Homotrimer; disulfide-linked.,

Cellular Localization:

Secreted . Cell surface . Secreted, extracellular space, extracellular matrix . Endoplasmic reticulum . Sarcoplasmic reticulum . Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity). .

Tissue Expression:

Aorta endothelial cell,Endothelial cell,Liver,Plasma,Platelet,Saliva,

Research Areas:

>>Rap1 signaling pathway ;
>>p53 signaling pathway ;
>>Phagosome ;
>>PI3K-Akt signaling pathway ;
>>TGF-beta signaling pathway ;
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Malaria ;
>>Human papillomavirus infection ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Bladder cancer