Main Information

Target

Secretogranin-1

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

IHC, IF, WB

MW

78kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; WB 1:500-2000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human Secretogranin-1

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

78kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human Secretogranin-1

Specificity:

This antibody detects endogenous levels of human Secretogranin-1

Gene Name:

CHGB SCG1

Protein Name:

Secretogranin-1

Other Name:

Secretogranin-1 ;
Chromogranin-B ;
CgB ;
Secretogranin I ;
SgI ;
[Cleaved into: GAWK peptide ;
CCB peptide]

Database Link:

Organism	Gene ID	SwissProt
Human	1114;	P05060;

Background:

This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009],

Function:

Function:Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.,PTM:Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues.,similarity:Belongs to the chromogranin/secretogranin protein family.,subcellular location:Neuroendocrine and endocrine secretory granules.,tissue specificity:Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.,

Cellular Localization:

Secreted. Neuroendocrine and endocrine secretory granules.

Tissue Expression:

Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.