Main Information

Target

ATG13

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

IHC, IF

MW

57kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-300; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

The antibody detects endogenous ATG13 protein

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

57kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Recombinant Protein of ATG13

Specificity:

The antibody detects endogenous ATG13 protein

Gene Name:

ATG13 KIAA0652

Protein Name:

Autophagy-related protein 13

Other Name:

Autophagy-related protein 13

Database Link:

Organism	Gene ID	SwissProt
Human	9776;	O75143;
Mouse		Q91YI1;

Background:

The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016],

Function:

autophagic vacuole formation, autophagy, vacuole organization, cellular response to starvation, response to extracellular stimulus, macroautophagy, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, cellular response to stress, response to starvation,

Cellular Localization:

Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. .

Tissue Expression:

Amygdala,Brain,

Research Areas:

>>Autophagy - other ;
>>Autophagy - animal ;
>>Longevity regulating pathway ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases