Main Information

Target

CACNB3

Host Species

Rabbit

Reactivity

Mouse, Rat

Applications

WB, IHC, IF

MW

50kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:500-1000; IHC 1:200-500; IF 1:50-200

Formulation

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Specificity

The antibody detects endogenous CACNB3 protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

MW(Observed)

50kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of CACNB3

Specificity:

The antibody detects endogenous CACNB3 protein.

Gene Name:

CACNB3

Protein Name:

Voltage-dependent L-type calcium channel subunit beta-3

Other Name:

CACNB3 ;
CACNLB3 ;
Voltage-dependent L-type calcium channel subunit beta-3 ;
CAB3 ;
Calcium channel voltage-dependent subunit beta 3

Database Link:

Organism	Gene ID	SwissProt
Human	784;	P54284;
Mouse		P54285;
Rat		P54287;

Background:

This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011],

Function:

Function:The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.,similarity:Belongs to the calcium channel beta subunit family.,similarity:Contains 1 SH3 domain.,subunit:The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with CACNA2D4.,tissue specificity:Expressed mostly in brain, smooth muscle and ovary.,

Cellular Localization:

Cytoplasm .

Tissue Expression:

Expressed mostly in brain, colon and ovary.

Research Areas:

>>MAPK signaling pathway ;
>>Cardiac muscle contraction ;
>>Adrenergic signaling in cardiomyocytes ;
>>Oxytocin signaling pathway ;
>>Hypertrophic cardiomyopathy ;
>>Arrhythmogenic right ventricular cardiomyopathy ;
>>Dilated cardiomyopathy