Main Information

Target

CACNG2

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB, IHC, IF

MW

36kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:1000-2000; IHC 1:200-500; IF 1:50-200

Formulation

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Specificity

The antibody detects endogenous CACNG2 protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

MW(Observed)

36kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of CACNG2 AA range: 58-108

Specificity:

The antibody detects endogenous CACNG2 protein.

Gene Name:

CACNG2

Protein Name:

Voltage-dependent calcium channel gamma-2 subunit

Other Name:

Voltage-dependent calcium channel gamma-2 subunit ;
Neuronal voltage-gated calcium channel gamma-2 subunit ;
Transmembrane AMPAR regulatory protein gamma-2 ;
TARP gamma-2

Database Link:

Organism	Gene ID	SwissProt
Human	10369;	Q9Y698;
Mouse		O88602;
Rat		Q71RJ2;

Background:

calcium voltage-gated channel auxiliary subunit gamma 2(CACNG2) Homo sapiens The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010],

Function:

Function:Thought to stabilize the calcium channel in an inactivated (closed) state.,PTM:Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC.,tissue specificity:Brain.,

Cellular Localization:

Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome .

Tissue Expression:

Brain.

Research Areas:

>>MAPK signaling pathway ;
>>Cardiac muscle contraction ;
>>Adrenergic signaling in cardiomyocytes ;
>>Oxytocin signaling pathway ;
>>Hypertrophic cardiomyopathy ;
>>Arrhythmogenic right ventricular cardiomyopathy ;
>>Dilated cardiomyopathy