Main Information

Target

CNTF

Host Species

Rabbit

Reactivity

Human, Rat, Mouse

Applications

WB

MW

30kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:500-1000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

CNTF protein(A218) detects endogenous levels of CNTF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

30kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of CNTF

Specificity:

CNTF protein(A218) detects endogenous levels of CNTF

Gene Name:

CNTF

Protein Name:

Ciliary neurotrophic factor (CNTF)

Other Name:

CNTF ;
Ciliary neurotrophic factor ;
CNTF

Database Link:

Organism	Gene ID	SwissProt
Human	1270;	P26441;
Mouse		P51642;
Rat		P20294;

Background:

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010],

Function:

Disease:Overexpressed in most acute myelogenous leukemia (AML) cases (27 over 29).,Function:CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.,Function:May be involved in transcriptional regulation. May play an important role in cell proliferation and/or anti-apoptosis.,online information:Ciliary neurotrophic factor entry,similarity:Belongs to the CNTF family.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subunit:Homodimer.,tissue specificity:Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.,tissue specificity:Nervous system.,

Cellular Localization:

Cytoplasm.

Tissue Expression:

Nervous system.

Research Areas:

>>Cytokine-cytokine receptor interaction ;
>>JAK-STAT signaling pathway