Main Information

Target

DUSP6

Host Species

Rabbit

Reactivity

Human, Rat, Mouse

Applications

WB

MW

42,44kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:1000-3000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

DUSP6 Rabbit Polyclonal detects endogenous levels of DUSP6

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

42,44kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of DUSP6

Specificity:

DUSP6 Rabbit Polyclonal detects endogenous levels of DUSP6

Gene Name:

DUSP6

Protein Name:

Dual specificity protein phosphatase 6 (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)

Other Name:

DUSP6 ;
MKP3 ;
PYST1 ;
Dual specificity protein phosphatase 6 ;
Dual specificity protein phosphatase PYST1 ;
Mitogen-activated protein kinase phosphatase 3 ;
MAP kinase phosphatase 3 ;
MKP-3

Database Link:

Organism	Gene ID	SwissProt
Human	1848;	Q16828;
Mouse		Q9DBB1;
Rat		Q64346;

Background:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in t

Function:

Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,Catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,Function:Inactivates MAP kinases. Has a specificity for the ERK family.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,

Cellular Localization:

Cytoplasm .

Tissue Expression:

Expressed in keratinocytes (at protein level).

Research Areas:

>>MAPK signaling pathway ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia