Target：CD21
Fields：Complement and coagulation cascades;Hematopoietic cell lineage;B cell receptor signaling pathway;Epstein-Barr virus infection
Gene Name：CR2
Protein Name：Complement receptor type 2
Human Gene Id：1380
Human Swiss Prot No：P20023
Mouse Swiss Prot No：P19070
Immunogen：Synthetic Peptide of CD21
Specificity：The antibody detects endogenous CD21 proteins.
Formulation：PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Source：Monoclonal, Mouse
Dilution：IHC 1:200 IF 1:50-200
Purification：The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CR2;C3DR;Complement receptor type 2;Cr2;Complement C3d receptor;Epstein-Barr virus receptor;EBV receptor;CD21
Observed Band(KD)：113kD
Background： This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],
Function：disease:Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:610927]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.,similarity:Belongs to the receptors of complement activation (RCA) family.,similarity:Contains 15 Sushi (CCP/SCR) domains.,tissue specificity:Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells
Subcellular Location：Cell membrane ; Single-pass type I membrane protein.
Expression：Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.
