Target：14-3-3-pan

Fields：Cell cycle;Oocyte meiosis;PI3K-Akt signaling pathway;Hippo signaling pathway;Hepatitis C;Hepatitis B;Viral carcinogenesis

Gene Name：YWHAB/YWHAG/YWHAQ/YWHAZ/SFN

Protein Name：14-3-3 protein beta/alpha/14-3-3 protein gamma/14-3-3 protein theta/14-3-3 protein zeta/delta/14-3-3 protein sigma

Human Gene Id：7529

Human Swiss Prot No：P31946

Mouse Gene Id：54401

Mouse Swiss Prot No：Q9CQV8

Rat Gene Id：56011

Rat Swiss Prot No：P35213

Immunogen：Synthesized acetyl-peptide derived from human 14-3-3-pan around the acetylation site of K51.

Specificity：Acetyl-14-3-3-pan (K51/49) Polyclonal Antibody detects endogenous levels of 14-3-3-pan around the acetylation site of K51 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：YWHAB;14-3-3 protein beta/alpha;Protein 1054;Protein kinase C inhibitor protein 1;KCIP-1;YWHAG;14-3-3 protein gamma;Protein kinase C inhibitor protein 1;KCIP-1;YWHAQ;14-3-3 protein theta;14-3-3 protein T-cell;14-3-3 protein tau;Protein HS1;YWHAZ;14-3-3 protein zeta/delta;Protein kinase C inhibitor protein 1;KCIP-1;SFN;HME1;14-3-3 protein sigma;Epithelial cell marker protein 1;Stratifin

Observed Band(KD)：30kD

Background： This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008],

Function：function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis.,PTM:Isoform Short contains a N-acetylmethionine at position 1.,PTM:The alpha, brain-specific form differs from the beta form in being phosphorylated.,similarity:Belongs to the 14-3-3 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB

Subcellular Location：Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; Vacuole membrane . (Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG. .

Expression： Brain,Colon carcinoma,Kerat