Target：HDAC1
Fields：Cell cycle;Longevity regulating pathway - multiple species;Notch signaling pathway;Neutrophil extracellular trap formation;Thyroid hormone signaling pathway;Huntington disease;Amphetamine addiction;Alcoholism;Human papillomavirus infection;Epstein-Barr virus infection;Pathways in cancer;Transcriptional misregulation in cancer;Viral carcinogenesis;MicroRNAs in cancer;Chronic myeloid leukemia
Gene Name：HDAC1
Protein Name：Histone deacetylase 1
Human Gene Id：3065
Human Swiss Prot No：Q13547
Mouse Gene Id：433759
Mouse Swiss Prot No：O09106
Rat Gene Id：297893
Rat Swiss Prot No：Q4QQW4
Immunogen：The antiserum was produced against synthesized peptide derived from human HDAC1 around the phosphorylation site of Ser421. AA range:387-436
Specificity：Phospho-HDAC1 (S421) Polyclonal Antibody detects endogenous levels of HDAC1 protein only when phosphorylated at S421.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：HDAC1;RPD3L1;Histone deacetylase 1;HD1
Observed Band(KD)：62kD
Background： Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008],
Function：catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.,PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates
Subcellular Location：Nucleus .
Expression：Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
