Target：Ah Receptor
Fields：Th17 cell differentiation;Cushing syndrome;Chemical carcinogenesis - receptor activation;Chemical carcinogenesis - reactive oxygen species
Gene Name：AHR
Protein Name：Aryl hydrocarbon receptor
Human Gene Id：196/57491
Human Swiss Prot No：P35869/A9YTQ3
Mouse Gene Id：11622/11624
Rat Gene Id：25690/498999
Rat Swiss Prot No：P41738/Q75NT5
Immunogen：The antiserum was produced against synthesized peptide derived from human AhR around the phosphorylation site of Ser36. AA range:2-51
Specificity：Phospho-Ah Receptor (S36) Polyclonal Antibody detects endogenous levels of Ah Receptor protein only when phosphorylated at S36.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：AHR;BHLHE76;Aryl hydrocarbon receptor;Ah receptor;AhR;Class E basic helix-loop-helix protein 76;bHLHe76;AHRR;BHLHE77;KIAA1234;Aryl hydrocarbon receptor repressor;AhR repressor;AhRR;Class E basic helix-loop-helix protein 77;bHL
Observed Band(KD)：75 or 96kD
Background： The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015],
Function：function:Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.,induction:Induced or repressed by TGF-beta and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and TPA.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subcellular location:Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.,subunit:Binds MYBBP1A (By similarity)
Subcellular Location：Cytoplasm . Nucleus . Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. .
Expression：Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Expressed in retinal photoreceptors (PubMed:29726989).
