Target：GATA-3
Fields：Th1 and Th2 cell differentiation;Th17 cell differentiation;Parathyroid hormone synthesis, secretion and action;Inflammatory bowel disease
Gene Name：GATA3
Protein Name：Trans-acting T-cell-specific transcription factor GATA-3
Human Gene Id：2625
Human Swiss Prot No：P23771
Mouse Gene Id：14462
Mouse Swiss Prot No：P23772
Immunogen：The antiserum was produced against synthesized peptide derived from human GATA3 around the phosphorylation site of Ser308. AA range:274-323
Specificity：Phospho-GATA-3 (S308) Polyclonal Antibody detects endogenous levels of GATA-3 protein only when phosphorylated at S308.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：GATA3;Trans-acting T-cell-specific transcription factor GATA-3;GATA-binding factor 3
Molecular Weight(Da)：48kD
Background： This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009],
Function：disease:Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.,function:Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.,similarity:Contains 2 GATA-type zinc fingers.,tissue specificity:T-cells and endothelial cells.,
Subcellular Location：Nucleus.
Expression：T-cells and endothelial cells.
