Target：NUDC
Gene Name：NUDC
Protein Name：Nuclear migration protein nudC
Human Gene Id：10726
Human Swiss Prot No：Q9Y266
Mouse Gene Id：18221
Mouse Swiss Prot No：O35685
Rat Gene Id：29648
Rat Swiss Prot No：Q63525
Immunogen：The antiserum was produced against synthesized peptide derived from human NudC around the phosphorylation site of Ser326. AA range:282-331
Specificity：Phospho-NUDC (S326) Polyclonal Antibody detects endogenous levels of NUDC protein only when phosphorylated at S326.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：NUDC;Nuclear migration protein nudC;Nuclear distribution protein C homolog
Observed Band(KD)：45kD
Background： This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012],
Function：function:Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.,induction:Up-regulated in actively dividing hematopoietic precursor cells. Up-regulated in cultured erythroleukemia TF-1 cells by granulocyte-macrophage colony-stimulating factor. Strongly down-regulated during maturation of erythroid precursor cells.,PTM:Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.,similarity:Belongs to the nudC family.,similarity:Contains 1 CS domain.,subcellular location:In a filamentous pattern adjacent to the nucleus of migrating cerebel
Subcellular Location：Cytoplasm, cytoskeleton. Nucleus . Cytoplasm, cytoskeleton, spindle . Midbody . In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern. Localizes to the mitotic spindle in a EML4-dependent manner (PubMed:25789526). .
Expression：Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
