Target：PDLIM5

Gene Name：PDLIM5

Protein Name：PDZ and LIM domain protein 5

Human Gene Id：10611

Human Swiss Prot No：Q96HC4

Mouse Swiss Prot No：Q8CI51

Immunogen：Synthesized phospho-peptide around the phosphorylation site of human PDLIM5 (phospho Tyr251)

Specificity：Phospho-PDLIM5 (Y251) Polyclonal Antibody detects endogenous levels of PDLIM5 protein only when phosphorylated at Y251.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PDLIM5;ENH;L9;PDZ and LIM domain protein 5;Enigma homolog;Enigma-like PDZ and LIM domains protein

Observed Band(KD)：64kD

Background： This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012],

Function：caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:May play a role in genetic susceptibility to schizophrenia. PDLIM5 is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.,function:May play an important role in the heart development by scaffolding PKC to the Z-disk region.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 3 LIM zinc-binding domains.,subunit:Interacts with various PKC isoforms through the LIM domains. Interacts with actin and alpha-actinin through the PDZ domain.,tissue specificity:Heart and skeletal muscle specific.,

Subcellular Location：Cell junction, synapse, postsynaptic density . Cell junction, synapse, presynapse . Cell junction, synapse, postsynapse . Cytoplasm, cytosol . Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons. .

Expression：Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.