Target：IKBKB

Fields：Antifolate resistance;MAPK signaling pathway;Ras signaling pathway;Chemokine signaling pathway;NF-kappa B signaling pathway;FoxO signaling pathway;mTOR signaling pathway;PI3K-Akt signaling pathway;Apoptosis;Osteoclast differentiation;Toll-like receptor signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Cytosolic DNA-sensing pathway;C-type lectin receptor signaling pathway;IL-17 signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;T cell receptor signaling pathway;B cell receptor signaling pathway;TNF signaling pathway;Neurotrophin signaling pathway;Insulin signaling pathway;Adipocytokine signaling pathway;Type II diabetes mellitus;Insulin resistance;Non-alcoholic fatty liver disease;Alcoholic liver disease;Alzheimer disease;Epithelial cell signaling in Helicobacter pylori infection;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Yer

Gene Name：IKBKB

Protein Name：Inhibitor of nuclear factor kappa-B kinase subunit beta

Human Gene Id：3551

Human Swiss Prot No：O14920

Mouse Gene Id：16150

Mouse Swiss Prot No：O88351

Rat Gene Id：84351

Rat Swiss Prot No：Q9QY78

Immunogen：The antiserum was produced against synthesized peptide derived from human IKK-beta around the phosphorylation site of Tyr188. AA range:161-210

Specificity：Phospho-IKKβ (Y188) Polyclonal Antibody detects endogenous levels of IKKβ protein only when phosphorylated at Y188.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IKBKB;IKKB;Inhibitor of nuclear factor kappa-B kinase subunit beta;I-kappa-B-kinase beta;IKK-B;IKK-beta;IkBKB;I-kappa-B kinase 2;IKK2;Nuclear factor NF-kappa-B inhibitor kinase beta;NFKBIKB

Observed Band(KD)：86kD

Background： The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011],

Function：catalytic activity:ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].,function:Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.,PTM:Ubiquitination on 'Ser-163' modulates phosphorylation on C-terminal serine residues.,PTM:Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-181 by MEKK1 and/or MAP3K14/NIK; which enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which decreases activity and prevents prolonged activation of the inflammatory response.,PTM:Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, which blocks the I-kappa-B signaling pathway.,similarity:Belongs to the p

Subcellular Location：Cytoplasm . Nucleus . Membrane raft . Colocalized with DPP4 in membrane rafts. .

Expression：Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.