Target：SP-A

Fields：Phagosome;Pertussis

Gene Name：SFTPA2/SFTPA1

Protein Name：Pulmonary surfactant-associated protein A2/Pulmonary surfactant-associated protein A1

Human Gene Id：729238

Human Swiss Prot No：Q8IWL1

Rat Gene Id：24773

Rat Swiss Prot No：P08427

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human SFTPA1/2. AA range:141-190

Specificity：SP-A Polyclonal Antibody detects endogenous levels of SP-A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SFTPA2;COLEC5;PSAP;SFTP1;SFTPA;SFTPA2B;Pulmonary surfactant-associated protein A2;PSP-A;PSPA;SP-A;SP-A2;35 kDa pulmonary surfactant-associated protein;Alveolar proteinosis protein;Collectin-5;SFTPA1;COLEC4;PSAP;SFTP1;SFTPA;SFTPA1B;Pulmonary surfactant-associated protein A1;PSP-A;PSPA;SP-A;SP-A1;35 kDa pulmonary surfactant-associated protein;Alveolar proteinosis protein;Collectin-4

Observed Band(KD)：34kD

Background： This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009],

Function：function:In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.,miscellaneous:Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).,polymorphism:At least 6 alleles of SFTPA2 are known: 1A, 1A(0), 1A(1), 1A(2), 1A(3) and 1A(4). The sequence shown is that of allele 1A(0).,similarity:Belongs to the SFTPA family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 collagen-like domain.,subunit:Oligomeric complex of 6 set of homotrimers.,

Subcellular Location：Secreted . Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.