Target:HS74L
Fields:Protein processing in endoplasmic reticulum
Gene Name:HSPA4L APG1 OSP94
Protein Name:Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94)
Human Gene Id:22824
Human Swiss Prot No:O95757
Mouse Swiss Prot No:P48722
Rat Swiss Prot No:P83581
Immunogen:Synthesized peptide derived from human protein . at AA range: 450-530
Specificity:HS74L Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):92kD
Background: The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],
Function:function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.,induction:By heat shock.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:May translocate to the nucleus after heat shock.,subunit:Homodimer.,
Subcellular Location:Cytoplasm . Nucleus . May translocate to the nucleus after heat shock. .
Expression: Heart,Testis,