Target：hnRNP L

Gene Name：HNRNPL

Protein Name：Heterogeneous nuclear ribonucleoprotein L

Human Gene Id：3191

Human Swiss Prot No：P14866

Mouse Gene Id：15388

Mouse Swiss Prot No：Q8R081

Immunogen：The antiserum was produced against synthesized peptide derived from human hnRNP L. AA range:61-110

Specificity：hnRNP L Polyclonal Antibody detects endogenous levels of hnRNP L protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HNRNPL;HNRPL;P/OKcl.14;Heterogeneous nuclear ribonucleoprotein L;hnRNP L

Observed Band(KD)：60kD

Background： Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different is

Function：function:This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. L is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.,PTM:Several isoelectric forms of the L protein are probably the results of post-translational modifications.,similarity:Contains 3 RRM (RNA recognition motif) domains.,

Subcellular Location：Nucleus, nucleoplasm . Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules. .

Expression： Brain,Cajal-Retzius cell,Fetal brain cortex,Keratinocyte,Pa