Target：SLC4A8/10

Gene Name：SLC4A8/SLC4A10

Protein Name：Electroneutral sodium bicarbonate exchanger 1/Sodium-driven chloride bicarbonate exchanger

Human Gene Id：57282/9498

Human Swiss Prot No：Q2Y0W8/Q6U841

Mouse Gene Id：59033/94229

Rat Gene Id：315311/295645

Rat Swiss Prot No：Q6RVG2/Q80ZA5

Immunogen：The antiserum was produced against synthesized peptide derived from human SLC4A8/10. AA range:411-460

Specificity：SLC4A8/10 Polyclonal Antibody detects endogenous levels of SLC4A8/10 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SLC4A8;KIAA0739;NBC;NBC3;NDCBE1;Electroneutral sodium bicarbonate exchanger 1;Electroneutral Na(+)-driven Cl-HCO3 exchanger;Solute carrier family 4 member 8;k-NBC3;SLC4A10;NCBE;Sodium-driven chloride bicarbonate exchanger;Solute

Observed Band(KD)：140kD

Background： The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],

Function：function:Mediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.,miscellaneous:Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anionic channels and transporters).,similarity:Belongs to the anion exchanger (TC 2.A.31) family.,tissue specificity:Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trache

Subcellular Location：Membrane ; Multi-pass membrane protein .

Expression：Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex.