Target：RXFP1

Fields：Neuroactive ligand-receptor interaction;Relaxin signaling pathway

Gene Name：RXFP1 LGR7

Protein Name：Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1)

Human Gene Id：59350

Human Swiss Prot No：Q9HBX9

Mouse Swiss Prot No：Q6R6I7

Rat Swiss Prot No：Q6R6I6

Immunogen：Synthesized peptide derived from human protein . at AA range: 240-320

Specificity：RXFP1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：83kD

Background： This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],

Function：function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 10 LRR (leucine-rich) repeats.,tissue specificity:Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.