Target：GROα

Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;Chemokine signaling pathway;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;IL-17 signaling pathway;TNF signaling pathway;Alcoholic liver disease;Epithelial cell signaling in Helicobacter pylori infection;Legionellosis;Amoebiasis;Kaposi sarcoma-associated herpesvirus infection;Rheumatoid arthritis;Lipid and atherosclerosis

Gene Name：CXCL1

Protein Name：Growth-regulated alpha protein

Human Gene Id：2919

Human Swiss Prot No：P09341

Mouse Gene Id：14825

Mouse Swiss Prot No：P12850

Rat Gene Id：81503

Rat Swiss Prot No：P14095

Immunogen：The antiserum was produced against synthesized peptide derived from human GROalpha. AA range:39-88

Specificity：GROα Polyclonal Antibody detects endogenous levels of GROα protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CXCL1;GRO;GRO1;GROA;MGSA;SCYB1;Growth-regulated alpha protein;C-X-C motif chemokine 1;GRO-alpha(1-73);Melanoma growth stimulatory activity;MGSA;Neutrophil-activating protein 3;NAP-3

Molecular Weight(Da)：11kD

Background： This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014],

Function：function:Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.,online information:CXCL1 entry,PTM:N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,

Subcellular Location：Secreted.

Expression： Blood,Ovary,Peripheral blood monocyte,Placenta,Skin,