Target：GRM3

Fields：Phospholipase D signaling pathway;Neuroactive ligand-receptor interaction;Glutamatergic synapse;Cocaine addiction

Gene Name：GRM3 GPRC1C MGLUR3

Protein Name：Metabotropic glutamate receptor 3 (mGluR3)

Human Gene Id：2913

Human Swiss Prot No：Q14832

Mouse Swiss Prot No：Q9QYS2

Rat Swiss Prot No：P31422

Immunogen：Synthesized peptide derived from human protein . at AA range: 40-120

Specificity：GRM3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：96kD

Background：glutamate metabotropic receptor 3(GRM3) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008],

Function：function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with GRASP.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.