Target：Gremlin-2
Fields：TGF-beta signaling pathway
Gene Name：GREM2 CKTSF1B2 DAND3 PRDC
Protein Name：Gremlin-2 (Cysteine knot superfamily 1, BMP antagonist 2) (DAN domain family member 3) (Protein related to DAN and cerberus)
Human Gene Id：64388
Human Swiss Prot No：Q9H772
Mouse Gene Id：23893
Mouse Swiss Prot No：O88273
Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human GREM2. AA range:71-120
Specificity：The antibody detects endogenous Gremlin-2
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Gremlin-2 (Cysteine knot superfamily 1, BMP antagonist 2;DAN domain family member 3;Protein related to DAN and cerberus)
Observed Band(KD)：19kD
Background： This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008],
Function：function:Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells.,similarity:Belongs to the DAN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,subunit:Interacts with BMP2 and BMP4.,
Subcellular Location：Secreted .
Expression： Brain,Colon,
