Target：GRB7
Gene Name：GRB7
Protein Name：Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Human Gene Id：2886
Human Swiss Prot No：Q14451
Mouse Gene Id：14786
Mouse Swiss Prot No：Q03160
Immunogen：Synthetic peptide from human protein at AA range: 30-100
Specificity：The antibody detects endogenous GRB7
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Growth factor receptor-bound protein 7 (B47;Epidermal growth factor receptor GRB-7;GRB7 adapter protein)
Background： The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011],
Function：alternative products:At least 2 isoforms are produced,function:Interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds to ERBB2.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the GRB7/10/14 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with RND1.,
Subcellular Location：Cytoplasm . Cell junction, focal adhesion . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic granule . Cell projection . Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions. .
Expression： Liver,Lung,Oesophageal carcinoma,Thalamus,
